• map-cpClifton Park Office

    1770 Route 9 Suite 202
    Clifton Park, NY 12065

    Phone: (518) 631-2933
    Fax: (518) 371-7102

    Directions

  • Schodack Office


    map-schSchodack Office

    1547 Columbia Turnpike
    Castleton, NY 12033

    Phone: (518) 479-4156
    Fax: (518) 479-3794

    Directions

  • Chatham Office


    map-chathChatham Office

    113 Hudson Avenue
    Chatham, NY 12037

    Phone: (518) 392-6742
    Fax: (518) 392-6019

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  • Schenectady Office


    map-schenSchenectady Office

    461 Clinton Street Extension Suite 1
    Schenectady, NY 12305

    Phone: (518) 374-7222
    Fax: (518) 374-2051

    Directions

  • A “Sunscreen Gene”?

    Posted by jody@upstatederm.com on Jun.04.18 in Skin Care

    Why do some people seem to be resistant to skin cancer, while many of us seem prone to it?

    Turns out there’s a gene that’s at least partially responsible, according to a recent study.When you expose your unprotected skin to UV radiation from the sun, DNA damage starts in skin cells almost immediately. If you have a healthy version of this gene, called the UV radiation resistance-associated gene (UVRAG for short), it rushes in to repair as much of the damage as possible.

    The gene is what’s known as a tumor suppressor, which means just what it sounds like: It helps stop cancer before it can start. In people who have a mutation of this gene, though, or low levels of the gene, it can’t clean up nearly as much of the damage. So those people are at higher risk of developing melanoma or other skin cancers. The study authors tested 340 melanoma patients and found that lower levels of the protective gene were linked to lower survival and more advanced metastases.

    The gene was actually discovered in the early ’90s as a factor in a UV light-sensitivity disorder called xeroderma pigmentosum, which puts patients at extremely high risk for skin cancer. Now we know this gene plays a role in everyone’s odds of getting skin cancer.

    Even if you have this protective gene, it can’t repair all of the damage the sun causes. Researchers hope this discovery may eventually lead to drugs that could help stimulate better repair of UV-damaged skin cells, says Yongfei Yang, a research associate at The University of Southern California Keck School of Medicine and lead author of the study. Meanwhile, it’s still crucial to protect yourself from the sun every single day.

    Published on May 20, 2016

    Skin Cancer Foundation

     

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