Posted by Upstate Dermatology on Apr.07.16 in Skin Care
Could a widespread facial skin disorder be a signal for other possible health problems? New studies are now revealing potential associations between rosacea and increased risks of cardiovascular disease, gastrointestinal disease, certain types of cancer and many other systemic illnesses. The National Rosacea Society (NRS) has designated April as Rosacea Awareness Month to alert the public to the early warning signs of this chronic and conspicuous facial disorder now estimated to affect more than 16 million Americans.
“Recently there have been a growing number of reports associating rosacea with a variety of potentially serious diseases,” said Dr. Richard Odom, professor of dermatology at the University of California-San Francisco. “Although it’s important to note that causal relationships between rosacea and these other diseases have not been demonstrated, this provides further reason for people who suspect they may have rosacea to seek diagnosis and appropriate treatment.”
In a recently published analysis of more than 33,000 patients with rosacea in Taiwan, researchers found that rosacea patients had a 41 percent greater risk of high cholesterol (dyslipidemia), a 35 percent higher risk of coronary artery disease and a 17 percent greater risk of high blood pressure (hypertension) than people without rosacea.1
In the well-known “Nurses Health Study II” – an ongoing biennial questionnaire on the medical history of 116,000 nurses since 1989 – the more than 6,000 women diagnosed with rosacea were 1.59 times more likely to have thyroid cancer and 1.5 times more likely to have basal cell carcinoma, a form of skin cancer, than those without rosacea.2 A recent clinical study of 130 individuals with rosacea at Johns Hopkins University also found a significant association between rosacea and allergies, respiratory diseases, gastroesophageal reflux disease (GERD), diabetes, urogenital diseases and female hormone imbalance.3 Other recent studies have found increased risks of inflammatory bowel disease and glioma, a form of brain cancer, in people with rosacea.4,5
“As with any research, the associations found in these early studies may possibly be influenced by various confounding factors that will be clarified over time as scientific investigation continues,” Dr. Odom said. “Nonetheless, until the significance of these relationships is definitively determined and understood, it is reasonable for people who suspect they may have rosacea to seek appropriate medical evaluation of their skin and, if appropriate, their general health as well.”
What Is Rosacea?
Rosacea is a common but poorly understood disorder of the facial skin that typically first strikes anytime after age 30, and may initially resemble a simple sunburn or an inexplicable blush. Suddenly, without warning, a flush comes to their cheeks, nose, chin or forehead. Then just when they start to feel concerned, the redness disappears.
Unfortunately, it happens again and again, becoming ruddier and lasting longer each time, and eventually visible blood vessels may appear. Without treatment, bumps and pimples often develop, growing more extensive over time, and burning, itching and stinging are common.
In severe cases, especially in men, the nose may become enlarged from the development of excess tissue. This is the condition that gave comedian W.C. Fields his trademark red, bulbous nose. In some people the eyes are also affected, feeling irritated and appearing watery or bloodshot. Severe cases of this condition, known as ocular rosacea, can result in reduced visual acuity.
Among the most famous rosacea sufferers is former President Bill Clinton, whose doctors disclosed that he had this condition in The New York Times. Others reported to have suffered from the disorder include Princess Diana, singer Sam Smith, model Dita Von Teese and comedian Amy Schumer.
Adding insult to injury is the common myth that rosacea sufferers who have an enlarged nose or ruddy complexion may be heavy drinkers. In fact, while alcohol may aggravate rosacea, these symptoms can be just as severe in a teetotaler. Another common misconception is that rosacea is caused by poor hygiene, when in reality it is unrelated to personal cleanliness.
According to NRS surveys, most rosacea patients have felt the negative emotional and social effects of their condition regardless of severity. In a survey of 1,675 rosacea patients, 90 percent said the disorder’s effect on their personal appearance had lowered their self-esteem and self-confidence, and 88 percent said they had suffered embarrassment. They also reported a wide range of negative feelings, including frustration, cited by 76 percent; anxiety and hopelessness, each noted by 54 percent; depression, 43 percent; anger, 34 percent; and isolation, 32 percent. Fifty-two percent of the respondents said they had avoided face-to-face contact because of the disorder. Among those with severe symptoms, 51 percent said they had even missed work because of their condition.
Research is now helping to dispel common misconceptions about the disorder by illuminating rosacea’s relationship to various internal and external factors that may be involved in its development. Through its patient-funded research grants program, the NRS has awarded over $1.4 million to support 61 studies that may lead to advances in its treatment and potential prevention or cure.
Ongoing research has suggested that rosacea may be caused by various possible factors, including irregularities of the immune system, nervous system, facial blood vessels and genetics, as well as the presence of microbes and Demodex mites on the skin. Meanwhile, there is now an expanding range of treatment options for its many potential signs and symptoms.
Although the definitive cause of rosacea remains unknown, a vast array of lifestyle and environmental factors has been found to trigger flare-ups of signs and symptoms in various individuals. Common rosacea triggers include sun exposure, emotional stress, hot or cold weather, wind, heavy exercise, alcohol, spicy foods, heated beverages, humidity, certain skin-care products and potentially an overabundance of Demodex mites.
“The good news is that rosacea can now be effectively controlled with medical therapy and lifestyle changes,” Dr. Odom said. “As medical research continues to reveal connections between the health of the skin and other parts of the body, further insights may also emerge into how to treat rosacea as well as improve overall health.”
Individuals with any of the following warning signs of rosacea are urged to see a dermatologist for diagnosis and appropriate treatment:
- Redness on the cheeks, nose, chin or forehead
- Small visible blood vessels on the face
- Bumps or pimples on the face
- Watery or irritated eyes
Sources: National Rosacea Society
1. Hua T-C, Chung P-I, Chen Y-J, et al. Cardiovascular comorbidities in patients with rosacea: a nationwide case-control study from Taiwan. J Am Acad Dermatol 2015;73:249-254.
2. Li W-Q, Zhang M, Danby FW, Han J, Qureshi AA. Personal history of rosacea and risk of incident cancer among women in the US. Br J Cancer 2015;113:520-523.
3. Rainer BM, Fischer AH, Luz Felipe da Silva DL, Kang S, Chien AL. Rosacea is associated with chronic systemic diseases in a skin severity dependent manner: results of a case-control study. J Am Acad Dermatol 2015;73:604-608.
4. Spoendlin J, Karatas G, Furlano RI, Jick SS, Meier CR. Rosacea in patients with ulcerative colitis and Crohn’s disease: a population-based case-control study. Inflamm Bowel Dis 2015 Dec 29. [Epub ahead of print]
5. Egeberg A, Hansen PR, Gislason GH, Thyssen JP. Association of rosacea with risk for glioma in a Danish nationwide cohort study. JAMA Dermatol 2016 Jan 27. Doi:10.1001/jamadermatol.2015.5549. [Epub ahead of print]